The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.
Over the past few years, it has become increasingly apparent that signal Baby transduction pathways are not merely linear cascades; they are organized into complex signaling networks that require high levels of regulation to generate precise and unique cell responses.However, the underlying regulatory mechanisms by which signaling pathways cross-co